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OLE1 stearoyl-CoA 9-desaturase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852825, updated on 24-Apr-2022

Summary

Gene symbol
OLE1
Gene description
stearoyl-CoA 9-desaturase
Primary source
SGD:S000003023
Locus tag
YGL055W
See related
AllianceGenome:SGD:S000003023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MDM2
Summary
Enables electron transfer activity and stearoyl-CoA 9-desaturase activity. Involved in mitochondrion inheritance; response to ethanol; and unsaturated fatty acid biosynthetic process. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See OLE1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (398628..400160)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Gep7p Neighboring gene Sds23p Neighboring gene cornichon family protein Neighboring gene tRNA-Glu

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the OLE1 gene: The OLE1 gene is conserved in mouse, rat, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Process Evidence Code Pubs
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in unsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stearoyl-CoA 9-desaturase
NP_011460.3
  • Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    398628..400160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180920.3NP_011460.3  TPA: stearoyl-CoA 9-desaturase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011460.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21147
    Conserved Domains (2) summary
    COG1398
    Location:92385
    OLE1; Fatty-acid desaturase [Lipid transport and metabolism]
    COG5274
    Location:408510
    CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]