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RAD6 E2 ubiquitin-conjugating protein RAD6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852822, updated on 5-Sep-2021

Summary

Gene symbol
RAD6
Gene description
E2 ubiquitin-conjugating protein RAD6
Primary source
SGD:S000003026
Locus tag
YGL058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSO8; UBC2
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Genomic context

See RAD6 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (393986..394504)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ybp2p Neighboring gene protein kinase PKP2 Neighboring gene Gep7p Neighboring gene Sds23p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RAD6 gene: The RAD6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single-stranded DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated transcription, termination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in error-free postreplication DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in error-free translesion synthesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in error-prone translesion synthesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dipeptide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
 
involved_in stress-induced homeostatically regulated protein degradation pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MUB1-RAD6-UBR2 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of Rad6-Rad18 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of UBR1-RAD6 ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of UBR1-RAD6 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E2 ubiquitin-conjugating protein RAD6
NP_011457.1
  • Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    393986..394504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180923.1NP_011457.1  TPA: E2 ubiquitin-conjugating protein RAD6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06104
    Conserved Domains (1) summary
    COG5078
    Location:1150
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
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