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PUS2 pseudouridine synthase PUS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852817, updated on 8-Aug-2022

Summary

Gene symbol
PUS2
Gene description
pseudouridine synthase PUS2
Primary source
SGD:S000003031
Locus tag
YGL063W
See related
AllianceGenome:SGD:S000003031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Located in mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PUS2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (383654..384766)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene ATP-dependent RNA helicase Neighboring gene pyruvate carboxylase 1 Neighboring gene Duo1p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables pseudouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tRNA pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA pseudouridine synthesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pseudouridine synthase PUS2
NP_011452.4
  • Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    383654..384766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180928.4NP_011452.4  TPA: pseudouridine synthase PUS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011452.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53167, Q06713
    UniProtKB/TrEMBL
    N1P5H6
    Conserved Domains (1) summary
    cd02568
    Location:1308
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like