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DBP3 RNA-dependent ATPase DBP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852802, updated on 18-Jan-2023

Summary

Gene symbol
DBP3
Gene description
RNA-dependent ATPase DBP3
Primary source
SGD:S000003046
Locus tag
YGL078C
See related
AllianceGenome:SGD:S000003046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA helicase activity. Involved in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See DBP3 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (360288..361859, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pyruvate transporter MPC1 Neighboring gene Kxd1p Neighboring gene Hnm1p Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in primary metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-dependent ATPase DBP3
NP_011437.3
  • RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    360288..361859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180943.3NP_011437.3  TPA: RNA-dependent ATPase DBP3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011437.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU66, P20447
    UniProtKB/TrEMBL
    A0A8H4C1E5, N1P1V8
    Conserved Domains (1) summary
    COG0513
    Location:88519
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]