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NUP145 nucleocytoplasmic transporter NUP145 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852788, updated on 24-Jan-2026
Official Symbol
NUP145
Official Full Name
nucleocytoplasmic transporter NUP145
Primary source
SGD:S000003060
Locus tag
YGL092W
See related
AllianceGenome:SGD:S000003060; FungiDB:YGL092W; VEuPathDB:YGL092W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RAT10
Summary
Enables RNA binding activity. A structural constituent of nuclear pore. Involved in several processes, including nuclear pore localization; nucleocytoplasmic transport; and regulation of gene expression. Part of nuclear pore central transport channel and nuclear pore outer ring. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See NUP145 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (337906..341859)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene poly(A)-specific ribonuclease Neighboring gene kinetochore-microtubule binding complex subunit SPC105 Neighboring gene Fe-S cluster-binding ATPase Neighboring gene Lif1p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor. Teixeira MT, et al. J Biol Chem, 1999 Nov 5. PMID 10542288
  2. Structures of the autoproteolytic domain from the Saccharomyces cerevisiae nuclear pore complex component, Nup145. Sampathkumar P, et al. Proteins, 2010 Jun. PMID 20310066, Free PMC Article
  3. C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure. Dockendorff TC, et al. Mol Cell Biol, 1997 Feb. PMID 9001245, Free PMC Article
  4. Defining the essential functional regions of the nucleoporin Nup145p. Emtage JL, et al. J Cell Sci, 1997 Apr. PMID 9133678
  5. Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia. Tosato V, et al. Front Oncol, 2017. PMID 29034209, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the C Terminus of Nup120 Directly Binds Nup145C and Nup85.
    Title: The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.
  2. crystal structure of the heterotrimeric Sec13 x Nup145C x Nup84 complex, centerpiece of the heptamer, at 3.2-A resolution. Nup84 forms a U-shaped alpha-helical solenoid domain, topologically similar to two other members of the heptamer, Nup145C and Nup85
    Title: Structure of a trimeric nucleoporin complex reveals alternate oligomerization states.
  3. The heterotypic ACE1 interaction of Nup84 and Nup145C is analogous to the homotypic ACE1 interaction of Sec31 that forms COPII lattice edge elements and is inconsistent with the alternative 'fence-like' NPC model.
    Title: Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
  4. By in vitro reconstitution, we demonstrate that Nup145N forms a nucleoporin subcomplex with Nup187. Moreover, we show that Nup145N binds to the heptameric Nup84 complex.
    Title: Reconstitution of Nup157 and Nup145N into the Nup84 complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of nuclear pore IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear pore localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to nuclear inner membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere tethering at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore central transport channel IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore cytoplasmic filaments IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
nucleocytoplasmic transporter NUP145
NP_011423.1
  • Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    337906..341859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180957.1 → NP_011423.1  nucleocytoplasmic transporter NUP145

    See identical proteins and their annotated locations for NP_011423.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU53, P49687
    UniProtKB/TrEMBL
    B3LHF7, N1P9Q0
    Conserved Domains (3) summary
    pfam04096
    Location:460 → 605
    Nucleoporin2; Nucleoporin autopeptidase
    pfam12110
    Location:898 → 1150
    Nup96; Nuclear protein 96
    pfam13634
    Location:34 → 122
    Nucleoporin_FG; Nucleoporin FG repeat region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49687.1

Gene LinkOut

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