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SPC105 kinetochore-microtubule binding complex subunit SPC105 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852787, updated on 7-Jun-2026
Official Symbol
SPC105
Official Full Name
kinetochore-microtubule binding complex subunit SPC105
Primary source
SGD:S000003061
Locus tag
YGL093W
See related
AllianceGenome:SGD:S000003061; FungiDB:YGL093W; VEuPathDB:YGL093W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; protein localization to kinetochore; and sister chromatid biorientation. Located in kinetochore. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SPC105 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (334886..337639)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Vps45p Neighboring gene poly(A)-specific ribonuclease Neighboring gene nucleocytoplasmic transporter NUP145 Neighboring gene Fe-S cluster-binding ATPase

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Unattached kinetochores drive their own capturing by sequestering a CLASP. Kolenda C, et al. Nat Commun, 2018 Feb 28. PMID 29491436, Free PMC Article
  2. The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling. Aravamudhan P, et al. Nat Cell Biol, 2015 Jul. PMID 26053220, Free PMC Article
  3. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore. Roy B, et al. Open Biol, 2022 Jan. PMID 35042402, Free PMC Article
  4. Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein. Benzi G, et al. Curr Genet, 2020 Dec. PMID 32632756
  5. The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint. Roy B, et al. Elife, 2020 Jun 1. PMID 32479259, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
    Title: Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
  2. Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
    Title: Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
  3. recruitment of PP1 to Spc105/Knl1 is carefully regulated to ensure that chromosome recruitment of PP1 to Spc105/Knl1 is carefully regulated to ensure that chromosome biorientation precedes SAC silencing, thereby ensuring accurate chromosome segregationprecedes SAC silencing, thereby ensuring accurate chromosome segregation
    Title: Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.
  4. Cnn1 regulates KMN (KNL1, MIS12 and NDC80 activity in a spatiotemporal manner by inhibiting the interaction between its complexes
    Title: Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
  5. the spc105p/kre28p complex has roles in kinetochore-microtubule binding and the spindle assembly checkpoint
    Title: Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in kinetochore assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic sister chromatid biorientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Knl1/Spc105 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Knl1/Spc105 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
kinetochore-microtubule binding complex subunit SPC105
NP_011422.1
  • Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    334886..337639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180958.1 → NP_011422.1  kinetochore-microtubule binding complex subunit SPC105

    See identical proteins and their annotated locations for NP_011422.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU52, P53148
    UniProtKB/TrEMBL
    A6ZU87, C7GW25, C8Z8F5, N1P1U6
    Conserved Domains (2) summary
    smart00787
    Location:450 → 756
    Spc7; Spc7 kinetochore protein
    pfam15402
    Location:70 → 424
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53148.1

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