ARC1 Arc1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ARC1
Gene description: Arc1p
Primary source: SGD:S000003073
Locus tag: YGL105W
See related: AllianceGenome:SGD:S000003073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme activator activity; phosphatidylinositol phosphate binding activity; and tRNA binding activity. Involved in positive regulation of ligase activity and tRNA aminoacylation for protein translation. Located in cytoplasmic stress granule. Part of methionyl glutamyl tRNA synthetase complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (307437..308567)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study suggests that the structure and function of Arc1p can be modulated via biotinylation in response to temperature changes.
Title: Modulating the Structure and Function of an Aminoacyl-tRNA Synthetase Cofactor by Biotinylation.
An ab initio model of both trimeric and the pentameric complexes containing Arc1,GluRS and MetRS.
Title: Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs.
dual localization of (c)ERS is controlled by binding to Arc1p
Title: Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS.
assembly of the Arc1p-synthetase complex is mediated exclusively by the N-terminal domains of the synthetases and that the two enzymes bind to largely independent sites on Arc1p.
Title: Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly.
These results are consistent with a model according to which Arc1p is a bifunctional protein involved in the subcellular localization of ScMetRS and ScGluRS via its N-terminal domain and of tRNA via its C-terminal domain.
Title: Arc1p is required for cytoplasmic confinement of synthetases and tRNA.
Present study suggests a more complex picture for Arc1p-mediated stimulation of yeast tRNA glutamylation than just a role in increasing the glutamyl-tRNA synthetase binding affinity for tRNAGlu.
Title: Role of Arc1p in the modulation of yeast glutamyl-tRNA synthetase activity.
The structure of the interacting domain of yeast glutamyl-tRNA synthetase (GluRS) and its accessory protein Arc1p was determined and refined to 1.9 A resolution.
Title: Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.
cytoplasmic location of Arc1p is maintained by Xpo1p-dependent nuclear export
Title: The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA aminoacylation for protein translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
part_of methionyl glutamyl tRNA synthetase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methionyl glutamyl tRNA synthetase complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Arc1p

NP_011410.1

Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

307437..308567

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180970.1 → NP_011410.1 TPA: Arc1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011410.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU41, P46672

UniProtKB/TrEMBL

A0A8H4C0A7, A6ZU76, B3LHG9, B5VIM1, C7GM22, C8Z8E3, N1P5E2

Conserved Domains (2) summary

cd10304
Location:22 → 119

GST_C_Arc1p_N_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Aminoacyl tRNA synthetase cofactor 1 and similar proteins

PLN02610
Location:193 → 376

PLN02610; probable methionyl-tRNA synthetase