TAF6 Taf6p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TAF6
Gene description: Taf6p
Primary source: SGD:S000003080
Locus tag: YGL112C
Gene type: protein coding
RNA name: Taf6p
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288c)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TAF60

Genomic context

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See TAF6 in Map Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (298178..299728, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

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Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the TAF6 gene: The TAF6 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
RNA polymerase II activating transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II activating transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
protein complex scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly	IC Inferred by Curator more info

Process	Evidence Code	Pubs
DNA-templated transcription, initiation	IEA Inferred from Electronic Annotation more info
RNA polymerase II transcriptional preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin organization	IDA Inferred from Direct Assay more info	PubMed
histone acetylation	IDA Inferred from Direct Assay more info	PubMed
regulation of sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-templated	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription, DNA-templated	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
SAGA complex	IDA Inferred from Direct Assay more info	PubMed
SLIK (SAGA-like) complex	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Names: Taf6p

NP_011403.1

Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

298178..299728 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180977.1 → NP_011403.1 TPA: Taf6p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011403.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P53040

Conserved Domains (2) summary

cd08050
Location:13 → 405

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

COG5095
Location:6 → 513

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]