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RPS2 40S ribosomal protein uS5 RPS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852754, updated on 12-Aug-2025
Official Symbol
RPS2
Official Full Name
40S ribosomal protein uS5 RPS2
Primary source
SGD:S000003091
Locus tag
YGL123W
See related
AllianceGenome:SGD:S000003091; FungiDB:YGL123W; VEuPathDB:YGL123W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPS4; SUP138; SUP38; SUP44
Summary
Enables small ribosomal subunit rRNA binding activity. A structural constituent of ribosome. Involved in positive regulation of translational fidelity and ribosomal subunit export from nucleus. Part of cytosolic small ribosomal subunit and small-subunit processome. Orthologous to human RPS2 (ribosomal protein S2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPS2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (277617..278381)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET13 Neighboring gene guanine nucleotide exchange factor MON1 Neighboring gene mRNA-binding protein NAB2 Neighboring gene Gpg1p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Methylation of yeast ribosomal protein S2 is elevated during stationary phase growth conditions. Ladror DT, et al. Biochem Biophys Res Commun, 2014 Mar 14. PMID 24486316, Free PMC Article
  2. Sequence and functional similarity between a yeast ribosomal protein and the Escherichia coli S5 ram protein. All-Robyn JA, et al. Mol Cell Biol, 1990 Dec. PMID 2247072, Free PMC Article
  3. Missense translation errors in Saccharomyces cerevisiae. Stansfield I, et al. J Mol Biol, 1998 Sep 11. PMID 9733638
  4. uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons in vivo. Dong J, et al. Genetics, 2022 Jan 4. PMID 34791232, Free PMC Article
  5. Asc1p/RACK1 Connects Ribosomes to Eukaryotic Phosphosignaling. Schmitt K, et al. Mol Cell Biol, 2017 Feb 1. PMID 27821475, Free PMC Article

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data report that Tsr4 cotranslationally associates with Rps2. Rps2 harbors a eukaryote-specific N-terminal extension that is critical for its interaction with Tsr4. Moreover, Tsr4 perturbation resulted in decreased Rps2 levels and phenocopied Rps2 depletion. Despite Rps2 joining nuclear pre-40S particles, Tsr4 appears to be restricted to the cytoplasm.
    Title: Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae.
  2. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
    Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
  3. Yeast in the stationary phase increase methylation of RPS2 in order to regulate ribosomal synthesis.
    Title: Methylation of yeast ribosomal protein S2 is elevated during stationary phase growth conditions.
  4. Rps2 is substoichiometrically modified at arginine-10 posttranslationally by small ribosomal subunit Rmt1 methyltransferase.
    Title: Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.
  5. These results are suggestive of a role for Rmt1 in modifying the function of Rps2 in a manner distinct from that occurring in S. pombe and mammalian cells.
    Title: Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
40S ribosomal protein uS5 RPS2
NP_011392.1
  • Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; N-terminal mitochondrial avoidance segment (MAS) required for targeting to nucleus; methylated on one or more arginine residues by Hmt1p; required for release of methyltransferase Bud23p from pre-40S precursor; homologous to mammalian ribosomal protein S2 and bacterial S5

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    277617..278381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180988.1 → NP_011392.1  TPA: 40S ribosomal protein uS5 RPS2

    See identical proteins and their annotated locations for NP_011392.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU25, P25443
    UniProtKB/TrEMBL
    A0A0L8VQS7, A0ABF7PIW4, A6ZU59, B3LHI3, C8Z8C7, G2WDX9, N1P1R7
    Conserved Domains (1) summary
    PTZ00070
    Location:31 → 252
    PTZ00070; 40S ribosomal protein S2; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25443.3

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