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Mpp2 MAGUK p55 scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85275, updated on 13-Apr-2024

Summary

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Official Symbol
Mpp2provided by RGD
Official Full Name
MAGUK p55 scaffold protein 2provided by RGD
Primary source
RGD:620014
See related
Ensembl:ENSRNOG00000059683 AllianceGenome:RGD:620014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlg2
Summary
Enables PDZ domain binding activity. A structural constituent of postsynaptic density. Involved in protein homooligomerization. Located in postsynaptic density. Is active in glutamatergic synapse. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 63.4), Lung (RPKM 14.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87511638..87544710, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87011434..87043883, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89998284..90030766, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480879 Neighboring gene Cd300 molecule-like family member G Neighboring gene pancreatic polypeptide Neighboring gene peptide YY

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Waldron S, et al. Genes Brain Behav, 2022 Apr. PMID 35075790, Free PMC Article
  2. Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function. Kim G, et al. Elife, 2016 Feb 12. PMID 26880549, Free PMC Article
  3. The PDZ protein MPP2 interacts with c-Src in epithelial cells. Baumgartner M, et al. Exp Cell Res, 2009 Oct 15. PMID 19665017
  4. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Rademacher N, et al. Sci Rep, 2016 Oct 19. PMID 27756895, Free PMC Article
  5. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, et al. Cell, 1998 Sep 18. PMID 9753324

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.
    Title: Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.
  2. proteins. Our results highlight a previously unexplored role for MPP2 at postsynaptic sites as a scaffold that links SynCAM1 cell adhesion molecules to core proteins of the postsynaptic density.
    Title: MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAGUK p55 subfamily member 2
Names
membrane palmitoylated protein 2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414214.1 → NP_001401143.1  MAGUK p55 subfamily member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    D3ZAA9, G3V8T8

  2. NM_001414222.1 → NP_001401151.1  MAGUK p55 subfamily member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    D3ZAA9, G3V8T8
    Related
    ENSRNOP00000072422.1, ENSRNOT00000092150.2

  3. NM_053513.2 → NP_445965.1  MAGUK p55 subfamily member 2

    See identical proteins and their annotated locations for NP_445965.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    D3ZAA9, G3V8T8
    Conserved Domains (5) summary
    smart00569
    Location:13 → 66
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229 → 287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359 → 540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68 → 119
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    87511638..87544710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270001.1 → XP_063126071.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    D3ZAA9, G3V8T8

  2. XM_063270002.1 → XP_063126072.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    D3ZAA9, G3V8T8

  3. XM_008768128.3 → XP_008766350.1  MAGUK p55 subfamily member 2 isoform X1

    See identical proteins and their annotated locations for XP_008766350.1

    UniProtKB/TrEMBL
    A0A8L2R7D6
    Related
    ENSRNOP00000073193.2
    Conserved Domains (6) summary
    smart00569
    Location:30 → 83
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:246 → 304
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:376 → 557
    GuKc; Guanylate kinase homologues
    cd00992
    Location:155 → 233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:366 → 556
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:85 → 136
    L27; L27 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZAA9.2 GenPept UniProtKB/Swiss-Prot:D3ZAA9

Gene LinkOut

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