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ITC1 Itc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852744, updated on 17-May-2024

Summary

Gene symbol
ITC1
Gene description
Itc1p
Primary source
FungiDB:YGL133W
Locus tag
YGL133W
See related
SGD:S000003101; AllianceGenome:SGD:S000003101; VEuPathDB:YGL133W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in negative regulation of transcription from RNA polymerase II promoter by pheromones and subtelomeric heterochromatin assembly. Located in nucleus. Part of CHRAC. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ITC1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (257707..261501)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Pcl10p Neighboring gene DNA-binding E3 ubiquitin-protein ligase SNT2 Neighboring gene mRNA guanylyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in subtelomeric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CHRAC IPI
Inferred from Physical Interaction
more info
PubMed 
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Itc1p
NP_011382.1
  • Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    257707..261501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180998.1NP_011382.1  TPA: Itc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011382.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU16, P53125
    UniProtKB/TrEMBL
    A0A8H4FA37, B3LHJ1, C7GX66, C8Z8B7, N1P1P5
    Conserved Domains (3) summary
    smart00571
    Location:423483
    DDT; domain in different transcription and chromosome remodeling factors
    pfam10537
    Location:24124
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15613
    Location:869952
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif