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AMS1 alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852721, updated on 24-Jan-2026
Official Symbol
AMS1
Official Full Name
alpha-mannosidase
Primary source
SGD:S000003124
Locus tag
YGL156W
See related
AllianceGenome:SGD:S000003124; FungiDB:YGL156W; VEuPathDB:YGL156W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-mannosidase activity. Involved in carbohydrate catabolic process; cellular response to glucose starvation; and cellular response to nitrogen starvation. Located in fungal-type vacuole membrane. Part of Cvt complex. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 2. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See AMS1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (210416..213667)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase RCK1 Neighboring gene carbonyl reductase (NADPH-dependent) ARI1 Neighboring gene protein geranylgeranyltransferase type I subunit CDC43 Neighboring gene holo-

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural heterogeneity in the Man8-13GlcNAc oligosaccharides from log-phase Saccharomyces yeast: a one- and two-dimensional 1H NMR spectroscopic study. Trimble RB, et al. Glycobiology, 1992 Feb. PMID 1550991
  2. A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiae. Yoshihisa T, et al. J Biol Chem, 1990 Dec 25. PMID 2266133
  3. Nucleotide sequence of AMS1, the structure gene of vacuolar alpha-mannosidase of Saccharomyces cerevisiae. Yoshihisa T, et al. Biochem Biophys Res Commun, 1989 Sep 15. PMID 2675832
  4. Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae. Yoshihisa T, et al. J Biol Chem, 1988 Apr 15. PMID 3281936
  5. Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae. Hutchins MU, et al. J Biol Chem, 2001 Jun 8. PMID 11264288, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
    Title: Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
  2. Atg34p and Atg19p have similar domain structures and are important for Ams1p transport during autophagy.
    Title: Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.
  3. Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
    Title: Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
  4. AMS1 of Saccharomyces cerevisiae, a cargo protein of the Cvt pathway, was crystallized.
    Title: Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cvt complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-mannosidase
NP_011359.1
  • Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    210416..213667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181021.1 → NP_011359.1  alpha-mannosidase

    See identical proteins and their annotated locations for NP_011359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTZ5, P22855
    UniProtKB/TrEMBL
    N1P6H0
    Conserved Domains (1) summary
    COG0383
    Location:44 → 1083
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22855.2

Gene LinkOut

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