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Bmp7 bone morphogenetic protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85272, updated on 16-Sep-2018

Summary

Official Symbol
Bmp7provided by RGD
Official Full Name
bone morphogenetic protein 7provided by RGD
Primary source
RGD:620743
See related
Ensembl:ENSRNOG00000053384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BMP-7
Summary
binds to cell surface heparan sulfate [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 205.4), Thymus (RPKM 29.5) and 6 other tissues See more
Orthologs

Genomic context

See Bmp7 in Genome Data Viewer
Location:
3q42
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170879972..170955820, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (176945362..177020745, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550368 Neighboring gene uncharacterized LOC103691984 Neighboring gene SPO11, initiator of meiotic double stranded breaks Neighboring gene ribonucleic acid export 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
BMP signaling pathway TAS
Traceable Author Statement
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
allantois development IEA
Inferred from Electronic Annotation
more info
 
allantois development ISO
Inferred from Sequence Orthology
more info
 
anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
axon guidance ISO
Inferred from Sequence Orthology
more info
 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell development ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
chorio-allantoic fusion IEA
Inferred from Electronic Annotation
more info
 
chorio-allantoic fusion ISO
Inferred from Sequence Orthology
more info
 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
embryonic pattern specification ISO
Inferred from Sequence Orthology
more info
 
embryonic skeletal joint morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal joint morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
eye development ISO
Inferred from Sequence Orthology
more info
 
heart trabecula morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
hindbrain development ISO
Inferred from Sequence Orthology
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
mesenchymal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
mesenchyme development ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
mesonephros development ISO
Inferred from Sequence Orthology
more info
 
metanephric mesenchymal cell proliferation involved in metanephros development IEA
Inferred from Electronic Annotation
more info
 
metanephric mesenchymal cell proliferation involved in metanephros development ISO
Inferred from Sequence Orthology
more info
 
metanephric mesenchyme morphogenesis IEA
Inferred from Electronic Annotation
more info
 
metanephric mesenchyme morphogenesis ISO
Inferred from Sequence Orthology
more info
 
metanephros development ISO
Inferred from Sequence Orthology
more info
 
monocyte aggregation IEA
Inferred from Electronic Annotation
more info
 
monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glomerular mesangial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of prostatic bud formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nephrogenic mesenchyme morphogenesis IEA
Inferred from Electronic Annotation
more info
 
nephrogenic mesenchyme morphogenesis ISO
Inferred from Sequence Orthology
more info
 
neural fold elevation formation IEA
Inferred from Electronic Annotation
more info
 
neural fold elevation formation ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
pattern specification process ISO
Inferred from Sequence Orthology
more info
 
pericardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluranon cable assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein 7
Names
bone moorphogenic protein-7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191856.2NP_001178785.1  bone morphogenetic protein 7 precursor

    See identical proteins and their annotated locations for NP_001178785.1

    Status: VALIDATED

    Source sequence(s)
    AABR07054830, AABR07054831
    UniProtKB/TrEMBL
    G3V6W8
    Related
    ENSRNOP00000070891.1, ENSRNOT00000084990.1
    Conserved Domains (2) summary
    smart00204
    Location:329430
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:34279
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    170879972..170955820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    160834683..160910334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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