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Zp1 zona pellucida glycoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85271, updated on 2-May-2024

Summary

Official Symbol
Zp1provided by RGD
Official Full Name
zona pellucida glycoprotein 1provided by RGD
Primary source
RGD:620604
See related
Ensembl:ENSRNOG00000020907 AllianceGenome:RGD:620604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ZP1-202
Summary
Predicted to be a structural constituent of egg coat. Predicted to be involved in single fertilization. Predicted to be located in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP1 (zona pellucida glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 1.3), Testes (RPKM 0.5) and 6 other tissues See more
Orthologs
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Genomic context

See Zp1 in Genome Data Viewer
Location:
1q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216984343..216993882, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207560881..207567261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226966366..226972746, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 109 Neighboring gene pre-mRNA processing factor 19 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene coiled-coil domain containing 86

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of egg coat IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of egg coat ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prevention of polyspermy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in egg coat IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in egg coat IEA
Inferred from Electronic Annotation
more info
 
located_in egg coat ISO
Inferred from Sequence Orthology
more info
 
located_in egg coat ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zona pellucida sperm-binding protein 1
Names
zona pellucida glycoprotein 1 (sperm receptor)
zp-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053509.1NP_445961.1  zona pellucida sperm-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_445961.1

    Status: VALIDATED

    Source sequence(s)
    AB000928
    UniProtKB/Swiss-Prot
    O54766
    UniProtKB/TrEMBL
    A6I072, G3V8U5
    Related
    ENSRNOP00000028396.1, ENSRNOT00000028396.3
    Conserved Domains (3) summary
    smart00018
    Location:224266
    PD; P or trefoil or TFF domain
    smart00241
    Location:269539
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:402537
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216984343..216993882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275900.1XP_063131970.1  zona pellucida sperm-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8T9JDG1
  2. XM_063275899.1XP_063131969.1  zona pellucida sperm-binding protein 1 isoform X1