U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BUD13 Bud13p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852701, updated on 6-Jul-2025
Official Symbol
BUD13
Official Full Name
Bud13p
Primary source
SGD:S000003142
Locus tag
YGL174W
See related
AllianceGenome:SGD:S000003142; FungiDB:YGL174W; VEuPathDB:YGL174W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CWC26
Summary
Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of RES complex. Orthologous to human BUD13 (BUD13 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See BUD13 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (174545..175345)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ssDNA endodeoxyribonuclease SAE2 Neighboring gene chromatin-binding exonuclease XRN1 Neighboring gene FG-nucleoporin NUP49

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel protein-protein interaction in the RES (REtention and Splicing) complex. Tripsianes K, et al. J Biol Chem, 2014 Oct 10. PMID 25160624, Free PMC Article
  2. An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex. Trowitzsch S, et al. J Biol Chem, 2008 Nov 21. PMID 18809678
  3. Structure of the yeast Pml1 splicing factor and its integration into the RES complex. Brooks MA, et al. Nucleic Acids Res, 2009 Jan. PMID 19033360, Free PMC Article
  4. QTL analysis of natural Saccharomyces cerevisiae isolates reveals unique alleles involved in lignocellulosic inhibitor tolerance. de Witt RN, et al. FEMS Yeast Res, 2019 Aug 1. PMID 31276593
  5. Retention and splicing complex (RES) - the importance of cooperativity. Wysoczanski P, et al. RNA Biol, 2016. PMID 26479714, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RES is a 71 kDa heterotrimer composed of the 3 proteins Pml1p, Bud13p and Snu17p. We solved the 3-dimensional structure of the core of the RES complex as well as the 2 dimers, Snu17p-Bud13p and Snu17p-Pml1p
    Title: Retention and splicing complex (RES) - the importance of cooperativity.
  2. The RES proteins Pml1 and Bud13 were shown to contact the intron downstream of the branch-site. A comparison of the B(act) crosslinking pattern versus that of B* and C complexes revealed that U2 and RES protein interactions with the intron are dynamic.
    Title: Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.
  3. An extended binding interface has been described between the Snu17p RNA recognition motif and Bud13p of the retention and splicing complex.
    Title: A novel protein-protein interaction in the RES (REtention and Splicing) complex.
  4. Snu17p RRM binds multiple ligand proteins and acts as a platform that displays functional modules of the ligands, including forkhead-associated domain of Pml1p and conserved polylysine motif of Bud13p
    Title: An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RES complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Bud13p
NP_011341.3
  • Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    174545..175345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181039.3 → NP_011341.3  TPA: Bud13p

    See identical proteins and their annotated locations for NP_011341.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTX8, P46947
    UniProtKB/TrEMBL
    A6ZU12, B3LHM6, C7GPN3, C8Z877, G2WDT1, N1P2W3
    Conserved Domains (1) summary
    pfam09736
    Location:120 → 249
    Bud13; Pre-mRNA-splicing factor of RES complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46947.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools