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COX4 cytochrome c oxidase subunit IV [ Saccharomyces cerevisiae S288C ]

Gene ID: 852688, updated on 12-Aug-2025
Official Symbol
COX4
Official Full Name
cytochrome c oxidase subunit IV
Primary source
SGD:S000003155
Locus tag
YGL187C
See related
AllianceGenome:SGD:S000003155; FungiDB:YGL187C; VEuPathDB:YGL187C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables zinc ion binding activity. Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (149704..150171, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein eS26 RPS26A Neighboring gene uncharacterized protein Neighboring gene Tpn1p Neighboring gene putative hydroxyacid dehydrogenase

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Translational regulation of nuclear gene COX4 expression by mitochondrial content of phosphatidylglycerol and cardiolipin in Saccharomyces cerevisiae. Su X, et al. Mol Cell Biol, 2006 Feb. PMID 16428432, Free PMC Article
  2. A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. Roise D, et al. EMBO J, 1986 Jun. PMID 3015598, Free PMC Article
  3. Identification of cytochrome c oxidase subunits in nuclear yeast mutants lacking the functional enzyme. Cabral F, et al. J Biol Chem, 1978 Jun 25. PMID 207698
  4. The control of translational accuracy is a determinant of healthy ageing in yeast. von der Haar T, et al. Open Biol, 2017 Jan. PMID 28100667, Free PMC Article
  5. The first twelve amino acids (less than half of the pre-sequence) of an imported mitochondrial protein can direct mouse cytosolic dihydrofolate reductase into the yeast mitochondrial matrix. Hurt EC, et al. EMBO J, 1985 Aug. PMID 2998781, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that Cox4 is a key factor for the biogenesis of complex IV, therefor mtHsp70-Mge1-Cox4 complex plays an important role in the formation of cytochrome c oxidase.
    Title: A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase.
  2. Studies indicate that Saccharomyces cerevisiae as a model system for mutation of mitochondrial cytochrome c oxidase subunits.
    Title: Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily.
  3. analysis of zinc binding in yeast Cox4
    Title: The characterization and role of zinc binding in yeast Cox4.
  4. Deletion analysis of the 5' UTR(COX4) revealed the presence of a 50-nucleotide fragment with two stem-loops as a cis-element inhibiting COX4 translation.
    Title: Translational regulation of nuclear gene COX4 expression by mitochondrial content of phosphatidylglycerol and cardiolipin in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial intermembrane space TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cytochrome c oxidase subunit IV
NP_011328.1
  • Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    149704..150171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181052.1 → NP_011328.1  TPA: cytochrome c oxidase subunit IV

    See identical proteins and their annotated locations for NP_011328.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBN6, D6VTW7, P04037
    UniProtKB/TrEMBL
    A0A0L8VQV1, A6ZU01, B3LHN6, C7GX07, C8Z865, G2WDR9, N1P6D5
    Conserved Domains (1) summary
    pfam01215
    Location:31 → 155
    COX5B; Cytochrome c oxidase subunit Vb
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04037.1

Gene LinkOut

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