U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARO8 bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852672, updated on 18-Jan-2023

Summary

Gene symbol
ARO8
Gene description
bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
Primary source
SGD:S000003170
Locus tag
YGL202W
See related
AllianceGenome:SGD:S000003170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 2-aminoadipate transaminase activity and aromatic-amino-acid:2-oxoglutarate aminotransferase activity. Involved in L-phenylalanine biosynthetic process and tyrosine biosynthetic process. Located in cytoplasm. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARO8 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (116059..117561)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene serine-type carboxypeptidase Neighboring gene tRNA-Lys Neighboring gene MCM DNA helicase complex subunit MCM6 Neighboring gene tRNA-Lys

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 2-aminoadipate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2-aminoadipate transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2-aminoadipate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables 2-aminoadipate transaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-phenylalanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables aromatic-amino-acid:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatic-amino-acid:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables aromatic-amino-acid:2-oxoglutarate aminotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
 
involved_in L-phenylalanine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-phenylalanine biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in aromatic amino acid family catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aromatic amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in tyrosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tyrosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tyrosine biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
NP_011313.1
  • Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; involved with Aro9p in production of kynurenic acid to detoxify excess tryptophan

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    116059..117561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181067.1NP_011313.1  TPA: bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011313.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTV2, P53090
    UniProtKB/TrEMBL
    A0A6C1E7J5, M4WKD8
    Conserved Domains (1) summary
    COG1167
    Location:5498
    ARO8; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]