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KEX1 serine-type carboxypeptidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852670, updated on 23-Apr-2026
Official Symbol
KEX1
Official Full Name
serine-type carboxypeptidase
Primary source
SGD:S000003171
Locus tag
YGL203C
See related
AllianceGenome:SGD:S000003171; FungiDB:YGL203C; VEuPathDB:YGL203C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables serine-type carboxypeptidase activity. Involved in apoptotic process. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See KEX1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (112475..114664, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane. Cooper A, et al. J Cell Biol, 1992 Dec. PMID 1469044, Free PMC Article
  2. Disruption of the KEX1 gene in Pichia pastoris allows expression of full-length murine and human endostatin. Boehm T, et al. Yeast, 1999 May. PMID 10341419
  3. Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae. Shilton BH, et al. Protein Sci, 1996 Feb. PMID 8745419, Free PMC Article
  4. Expression, purification, and characterization of the yeast KEX1 gene product, a polypeptide precursor processing carboxypeptidase. Latchinian-Sadek L, et al. J Biol Chem, 1993 Jan 5. PMID 8416959
  5. Secretion, purification and characterization of a soluble form of the yeast KEX1-encoded protein from insect-cell cultures. Latchinian-Sadek L, et al. Eur J Biochem, 1994 Jan 15. PMID 8307029

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protease Kex1p appears to mediate HOClinduced lethality, since its absence enhances cell viability and decreases levels of ROS as well as formation of HOCl-modified epitopes upon challenge with lethal doses of HOCl.
    Title: The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast.
  2. Kex1 contributes also to the active cell death program induced by acetic acid stress or during chronological aging, suggesting that Kex1 plays a more general role in cellular suicide of yeast.
    Title: Kex1 protease is involved in yeast cell death induced by defective N-glycosylation, acetic acid, and chronological aging.
  3. Kex2 and Kex1 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both.
    Title: The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
serine-type carboxypeptidase
NP_011312.1
  • Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    112475..114664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181068.1 → NP_011312.1  serine-type carboxypeptidase

    See identical proteins and their annotated locations for NP_011312.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTV1, P09620
    UniProtKB/TrEMBL
    G2WDQ4
    Conserved Domains (1) summary
    COG2939
    Location:1 → 498
    Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09620.1

Gene LinkOut

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