POX1 acyl-CoA oxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: POX1
Official Full Name: acyl-CoA oxidase
Primary source: SGD:S000003173
Locus tag: YGL205W
See related: AllianceGenome:SGD:S000003173; FungiDB:YGL205W; VEuPathDB:YGL205W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FOX1
Summary: Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA oxidase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables acyl-CoA oxidase activity	RCA inferred from Reviewed Computational Analysis more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

NP_011310.1

Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; component of a light sensing pathway, converting light into a hydrogen peroxide signal, modulating nucleo-cytoplasmic shuttling of stress-responsive transcription factor, Msn2p