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PDE1 3',5'-cyclic-nucleotide phosphodiesterase PDE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852644, updated on 5-Jul-2025
Official Symbol
PDE1
Official Full Name
3',5'-cyclic-nucleotide phosphodiesterase PDE1
Primary source
SGD:S000003217
Locus tag
YGL248W
See related
AllianceGenome:SGD:S000003217; FungiDB:YGL248W; VEuPathDB:YGL248W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PDE1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (35653..36762)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rmr1p Neighboring gene Zip2p Neighboring gene ncRNA Neighboring gene Brr6p Neighboring gene decapping nuclease

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cyclic nucleotide specific phosphodiesterases of Leishmania major. Johner A, et al. BMC Microbiol, 2006 Mar 8. PMID 16522215, Free PMC Article
  2. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Tian Y, et al. Biochemistry, 2014 Aug 5. PMID 25050706, Free PMC Article
  3. Glucose exerts opposite effects on mRNA versus protein and activity levels of Pde1, the low-affinity cAMP phosphodiesterase from budding yeast, Saccharomyces cerevisiae. Wera S, et al. FEBS Lett, 1997 Dec 29. PMID 9459299
  4. Expression of human recombinant cAMP phosphodiesterase isozyme IV reverses growth arrest phenotypes in phosphodiesterase-deficient yeast. McHale MM, et al. Mol Pharmacol, 1991 Feb. PMID 1847489
  5. TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi. Alonso GD, et al. Mol Biochem Parasitol, 2007 Mar. PMID 17222469

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast PDE1 shares a common mechanism for hydrolysis of cyclic adenosine AMP and cyclic guanosine GMP.
    Title: Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
  2. deletion of PDE1 did not affect stress tolerance, although it exacerbated stress sensitivity caused by the pde2 deletion, indicating that PDE1 can partly compensate for PDE2
    Title: The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glucose mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
3',5'-cyclic-nucleotide phosphodiesterase PDE1
NP_011266.1
  • Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    35653..36762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181114.1 → NP_011266.1  TPA: 3',5'-cyclic-nucleotide phosphodiesterase PDE1

    See identical proteins and their annotated locations for NP_011266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV87, P22434
    UniProtKB/TrEMBL
    A6ZTU3, B3LHU0, C7GNZ4, C8Z810, N1P9P4
    Conserved Domains (1) summary
    COG5212
    Location:7 → 369
    PDE1; cAMP phosphodiesterase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22434.2

Gene LinkOut

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