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OST5 dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 852625, updated on 4-Feb-2026
Official Symbol
OST5
Official Full Name
dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
Primary source
SGD:S000003194
Locus tag
YGL226C-A
See related
AllianceGenome:SGD:S000003194; FungiDB:YGL226C-A; VEuPathDB:YGL226C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See OST5 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
2
Sequence:
Chromosome: VII; NC_001139.9 (72749..73158, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene She10p Neighboring gene glucose-induced degradation complex subunit VID30 Neighboring gene tRNA-Val Neighboring gene Mtc3p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides. Kelleher DJ, et al. J Biol Chem, 1994 Apr 29. PMID 8175708
  2. Studies of yeast oligosaccharyl transferase subunits using the split-ubiquitin system: topological features and in vivo interactions. Yan A, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15886282, Free PMC Article
  3. The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex. Knauer R, et al. J Biol Chem, 1999 Jun 11. PMID 10358084
  4. The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p. Karaoglu D, et al. J Biol Chem, 1997 Dec 19. PMID 9405463
  5. The atomic structure of a eukaryotic oligosaccharyltransferase complex. Bai L, et al. Nature, 2018 Mar 15. PMID 29466327, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
NP_011288.1
  • Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    72749..73158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181091.1 → NP_011288.1  dolichyl-diphosphooligosaccharide--protein glycotransferase subunit

    See identical proteins and their annotated locations for NP_011288.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVA8, P87030, Q92316
    UniProtKB/TrEMBL
    A6ZTW4, B3LHR9, C8Z828, G2WDN3, N1P5W7
    Conserved Domains (1) summary
    pfam05251
    Location:14 → 86
    Ost5; Oligosaccharyltransferase subunit 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92316.2

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