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DOC1 anaphase promoting complex subunit DOC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852611, updated on 23-Apr-2026
Official Symbol
DOC1
Official Full Name
anaphase promoting complex subunit DOC1
Primary source
SGD:S000003209
Locus tag
YGL240W
See related
AllianceGenome:SGD:S000003209; FungiDB:YGL240W; VEuPathDB:YGL240W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APC10
Summary
Enables enzyme regulator activity. Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and chromatin organization. Located in mitochondrion. Part of anaphase-promoting complex. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See DOC1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (48613..49365)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ankyrin repeat-containing protein ANK1 Neighboring gene karyopherin KAP114 Neighboring gene importin-alpha export receptor Neighboring gene transcription activator HAP2

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. Au SW, et al. J Mol Biol, 2002 Mar 1. PMID 11884135
  2. A process independent of the anaphase-promoting complex contributes to instability of the yeast S phase cyclin Clb5. Sari F, et al. J Biol Chem, 2007 Sep 7. PMID 17620341
  3. Discrete regions of the kinesin-8 Kip3 tail differentially mediate astral microtubule stability and spindle disassembly. Dave S, et al. Mol Biol Cell, 2018 Aug 1. PMID 29874146, Free PMC Article
  4. The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation. Menzel J, et al. Genetics, 2014 Mar. PMID 24361936, Free PMC Article
  5. Spindle assembly requires complete disassembly of spindle remnants from the previous cell cycle. Woodruff JB, et al. Mol Biol Cell, 2012 Jan. PMID 22090343, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The anaphase-promoting complex/cyclosome (APC/C) is suppressed by the small pseudosubstrate inhibitor Acm1. Acm1 D-box extension inhibits reaction processivity by perturbing the normal interaction with Doc1/Apc10. These results reveal a simple, elegant mode of pseudosubstrate inhibition that combines high-affinity activator binding with specific disruption of Doc1/Apc10 function in processive ubiquitylation.
    Title: The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
  2. Formation of a complete APC/C-activator-substrate complex leads to a major enhancement of E2 efficiency.
    Title: Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.
  3. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.
    Title: Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.
  4. Doc1 contributes to recognition of the substrate destruction box by the anaphase-promoting complex.
    Title: The APC subunit Doc1 promotes recognition of the substrate destruction box.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anaphase promoting complex subunit DOC1
NP_011274.2
  • Processivity factor; required for ubiquitination activity of anaphase promoting complex (APC), mediates the activity of APC by contributing to substrate recognition; involved in cyclin proteolysis; contains conserved DOC1 homology domain

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    48613..49365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181106.1 → NP_011274.2  anaphase promoting complex subunit DOC1

    See identical proteins and their annotated locations for NP_011274.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV95, P53068
    UniProtKB/TrEMBL
    A6ZTV1, B3LHT2, C7GNY6, G2WDM0, N1P204
    Conserved Domains (1) summary
    COG5156
    Location:59 → 248
    DOC1; Anaphase-promoting complex (APC), subunit 10 [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53068.2

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