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KAP114 karyopherin KAP114 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852610, updated on 7-Jun-2026
Official Symbol
KAP114
Official Full Name
karyopherin KAP114
Primary source
SGD:S000003210
Locus tag
YGL241W
See related
AllianceGenome:SGD:S000003210; FungiDB:YGL241W; VEuPathDB:YGL241W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See KAP114 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (45445..48459)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-specific adenosine deaminase Neighboring gene ankyrin repeat-containing protein ANK1 Neighboring gene anaphase promoting complex subunit DOC1 Neighboring gene importin-alpha export receptor

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. Liao CC, et al. Nat Commun, 2023 Sep 8. PMID 37684250, Free PMC Article
  2. A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B. Mosammaparast N, et al. EMBO J, 2002 Dec 2. PMID 12456659, Free PMC Article
  3. Involvement of nucleocytoplasmic shuttling of yeast Nap1 in mitotic progression. Miyaji-Yamaguchi M, et al. Mol Cell Biol, 2003 Sep. PMID 12944491, Free PMC Article
  4. The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein. Morehouse H, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535958, Free PMC Article
  5. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. Fung HYJ, et al. J Cell Biol, 2025 Jan 6. PMID 39601790, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein.
    Title: Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein.
  2. It is proposed that sumoylation occurs at the site of Kap114 cargo function and that small ubiquitin-related modifier is a cargo release factor involved in intranuclear targeting.
    Title: Sumoylation regulates Kap114-mediated nuclear transport.
  3. Kap114p, responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones H2A and H2B by the histone chaperone Nap1p.
    Title: Modulation of histone deposition by the karyopherin kap114.
  4. TFIIB nuclear import is mediated by Kap114p
    Title: Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains.
  5. The KAP114 protein functions is in a parallel import pathway for H2A and H2B.
    Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables H2A-H2B histone complex chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear import signal receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
karyopherin KAP114
NP_011273.1
  • Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    45445..48459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181107.1 → NP_011273.1  karyopherin KAP114

    See identical proteins and their annotated locations for NP_011273.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV94, P53067
    UniProtKB/TrEMBL
    C7GNY7, N1P3A8
    Conserved Domains (1) summary
    COG5657
    Location:10 → 165
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53067.1

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