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TAD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852608, updated on 11-Sep-2024

Summary

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Official Symbol
TAD1
Primary source
SGD:S000003212
Locus tag
YGL243W
See related
AllianceGenome:SGD:S000003212; FungiDB:YGL243W; VEuPathDB:YGL243W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA-specific adenosine-37 deaminase activity. Involved in tRNA modification. Located in nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (43307..44509)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase GUS1 Neighboring gene Rtf1p Neighboring gene Ank1p Neighboring gene Kap114p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. Gerber A, et al. EMBO J, 1998 Aug 17. PMID 9707437, Free PMC Article
  2. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article
  3. A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome. Srikumar T, et al. Mol Syst Biol, 2013 May 28. PMID 23712011, Free PMC Article
  4. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Gallina I, et al. Nat Commun, 2015 Mar 30. PMID 25817432, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine-37 deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine-37 deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-specific adenosine-37 deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble adenosine to inosine editing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
tRNA-specific adenosine deaminase
NP_011271.1
  • tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    43307..44509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181109.1 → NP_011271.1  TPA: tRNA-specific adenosine deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV92, P53065
    UniProtKB/TrEMBL
    B3LHT5
    Conserved Domains (1) summary
    smart00552
    Location:22 → 400
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53065.1

Gene LinkOut

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