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TAD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852608, updated on 22-Aug-2024

Summary

Official Symbol
TAD1
Primary source
FungiDB:YGL243W
Locus tag
YGL243W
See related
SGD:S000003212; AllianceGenome:SGD:S000003212; VEuPathDB:YGL243W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA-specific adenosine-37 deaminase activity. Involved in tRNA modification. Located in nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (43307..44509)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase GUS1 Neighboring gene Rtf1p Neighboring gene Ank1p Neighboring gene Kap114p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-specific adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-specific adenosine-37 deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA-specific adenosine-37 deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA-specific adenosine-37 deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble adenosine to inosine editing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

Preferred Names
tRNA-specific adenosine deaminase
NP_011271.1
  • tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    43307..44509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181109.1NP_011271.1  TPA: tRNA-specific adenosine deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV92, P53065
    UniProtKB/TrEMBL
    B3LHT5
    Conserved Domains (1) summary
    smart00552
    Location:22400
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)