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GUS1 glutamate--tRNA ligase GUS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852606, updated on 25-Jan-2022

Summary

Gene symbol
GUS1
Gene description
glutamate--tRNA ligase GUS1
Primary source
SGD:S000003214
Locus tag
YGL245W
See related
AllianceGenome:SGD:S000003214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GSN1
Summary
Enables glutamate-tRNA ligase activity. Involved in glutamyl-tRNA aminoacylation. Located in cytoplasmic stress granule and mitochondrion. Part of methionyl glutamyl tRNA synthetase complex. [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See GUS1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (39023..41149)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Brr6p Neighboring gene decapping nuclease Neighboring gene Rtf1p Neighboring gene tRNA-specific adenosine deaminase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GUS1 gene: The GUS1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutamyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of methionyl glutamyl tRNA synthetase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of methionyl glutamyl tRNA synthetase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate--tRNA ligase GUS1
NP_011269.2
  • Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    39023..41149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181111.1NP_011269.2  TPA: glutamate--tRNA ligase GUS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011269.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46655
    Conserved Domains (2) summary
    TIGR00463
    Location:102696
    gltX_arch; glutamyl-tRNA synthetase, archaeal and eukaryotic family
    cl02776
    Location:72128
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
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