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APM3 Apm3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852591, updated on 7-Apr-2025

Summary

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Official Symbol
APM3
Official Full Name
Apm3p
Primary source
SGD:S000000492
Locus tag
YBR288C
See related
AllianceGenome:SGD:S000000492; FungiDB:YBR288C; VEuPathDB:YBR288C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKS6
Summary
Involved in Golgi to vacuole transport and protein targeting to vacuole. Part of AP-3 adaptor complex. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1) and AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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Genomic context

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See APM3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (778012..779463, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene aminopeptidase Y Neighboring gene uncharacterized protein Neighboring gene Snf5p Neighboring gene Bsd2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Renard HF, et al. Traffic, 2010 Jul 1. PMID 20406419
  2. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Wen W, et al. Mol Biol Cell, 2006 Oct. PMID 16855025, Free PMC Article
  3. A microscopy-based kinetic analysis of yeast vacuolar protein sorting. Casler JC, et al. Elife, 2020 Jun 25. PMID 32584255, Free PMC Article
  4. Generation of null alleles for the functional analysis of six genes from the right arm of Saccharomyces cerevisiae chromosome II. Dueñas E, et al. Yeast, 1999 May. PMID 10341424
  5. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. Stepp JD, et al. J Cell Biol, 1997 Dec 29. PMID 9412470, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apm3p
NP_009847.4
  • Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    778012..779463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178636.4 → NP_009847.4  TPA: Apm3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009847.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQT3, P38153
    UniProtKB/TrEMBL
    A6ZLM6, B3LMM5, C7GMU4, N1P795
    Conserved Domains (1) summary
    cl10970
    Location:199 → 482
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38153.2

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