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SRB6 Srb6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852555, updated on 30-Jul-2025
Official Symbol
SRB6
Official Full Name
Srb6p
Primary source
SGD:S000000457
Locus tag
YBR253W
See related
AllianceGenome:SGD:S000000457; FungiDB:YBR253W; VEuPathDB:YBR253W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED22
Summary
Predicted to enable transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SRB6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (723270..723635)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein uS5m MRPS5 Neighboring gene bifunctional dITP/dUTP diphosphatase Neighboring gene TRAPP subunit TRS20 Neighboring gene Mtc4p

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An RNA polymerase II holoenzyme responsive to activators. Koleske AJ, et al. Nature, 1994 Mar 31. PMID 8133894
  2. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo. Lee D, et al. Nature, 1998 May 28. PMID 9620805
  3. General requirement for RNA polymerase II holoenzymes in vivo. Thompson CM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753848, Free PMC Article
  4. Interaction of the mediator head module with RNA polymerase II. Cai G, et al. Structure, 2012 May 9. PMID 22579255, Free PMC Article
  5. An activator target in the RNA polymerase II holoenzyme. Koh SS, et al. Mol Cell, 1998 May. PMID 9660972

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Srb6p
NP_009812.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    723270..723635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178601.1 → NP_009812.1  TPA: Srb6p

    See identical proteins and their annotated locations for NP_009812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQP9, P32570
    UniProtKB/TrEMBL
    A6ZLJ2, B3LMQ9, C7GMX8, D3UF00, G2W9Q6, N1P8K3
    Conserved Domains (1) summary
    pfam06179
    Location:8 → 117
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32570.1

Gene LinkOut

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