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PDB1 pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 852522, updated on 15-Mar-2026
Official Symbol
PDB1
Official Full Name
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Primary source
SGD:S000000425
Locus tag
YBR221C
See related
AllianceGenome:SGD:S000000425; FungiDB:YBR221C; VEuPathDB:YBR221C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrial nucleoid. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PDB1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (665153..666253, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Pcs60p

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of PDH beta 1, the structural gene for the pyruvate dehydrogenase beta subunit from Saccharomyces cerevisiae. Miran SG, et al. Proc Natl Acad Sci U S A, 1993 Feb 15. PMID 8433986, Free PMC Article
  2. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism. Eder M, et al. Sci Rep, 2020 Feb 7. PMID 32034164, Free PMC Article
  3. Genetic analysis of the Warburg effect in yeast. Olayanju B, et al. Adv Biol Regul, 2015 Jan. PMID 25446884, Free PMC Article
  4. Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex. Lawson JE, et al. Biochemistry, 1991 Mar 19. PMID 2007123
  5. Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Maeng CY, et al. Biochemistry, 1994 Nov 22. PMID 7947791

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
    Title: QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyruvate decarboxylation to acetyl-CoA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate decarboxylation to acetyl-CoA IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate decarboxylation to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate decarboxylation to acetyl-CoA NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
NP_009780.1
  • E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    665153..666253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178569.1 → NP_009780.1  pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

    See identical proteins and their annotated locations for NP_009780.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQL7, P32473
    UniProtKB/TrEMBL
    A6ZLG0, B3LMU1, B5VEH3, C7GMT2, D3UEW6, G2W9M4, N1P8H2
    Conserved Domains (1) summary
    PRK11892
    Location:6 → 362
    PRK11892; pyruvate dehydrogenase subunit beta; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32473.2

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