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PYC2 pyruvate carboxylase 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852519, updated on 24-Jan-2026
Official Symbol
PYC2
Official Full Name
pyruvate carboxylase 2
Primary source
SGD:S000000422
Locus tag
YBR218C
See related
AllianceGenome:SGD:S000000422; FungiDB:YBR218C; VEuPathDB:YBR218C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pyruvate carboxylase activity. Involved in gluconeogenesis. Located in cytosol. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PYC2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (658707..662249, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ybp1p Neighboring gene Atg12p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Regulation of pyc1 encoding pyruvate carboxylase isozyme I by nitrogen sources in Saccharomyces cerevisiae. Huet C, et al. Eur J Biochem, 2000 Dec. PMID 11082192
  2. Pyruvate carboxylase from baker's yeast. The presence of bound zinc. Scrutton MC, et al. J Biol Chem, 1970 Nov 25. PMID 5484476
  3. Human genetic diseases: a cross-talk between man and yeast. Foury F. Gene, 1997 Aug 11. PMID 9300813
  4. Regulatory regions in the promoters of the Saccharomyces cerevisiae PYC1 and PYC2 genes encoding isoenzymes of pyruvate carboxylase. Menéndez J, et al. FEMS Microbiol Lett, 1998 Jul 15. PMID 9682484
  5. Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Brewster NK, et al. Arch Biochem Biophys, 1994 May 15. PMID 8185321

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate carboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pyruvate carboxylase 2
NP_009777.1
  • Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    658707..662249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178566.1 → NP_009777.1  pyruvate carboxylase 2

    See identical proteins and their annotated locations for NP_009777.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQL4, P32327
    UniProtKB/TrEMBL
    A6ZLF8, B3LMU2, G2W9M1
    Conserved Domains (1) summary
    COG1038
    Location:15 → 1171
    PycA; Pyruvate carboxylase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32327.2

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