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HPC2 Hpc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852516, updated on 15-Mar-2026
Official Symbol
HPC2
Official Full Name
Hpc2p
Primary source
SGD:S000000419
Locus tag
YBR215W
See related
AllianceGenome:SGD:S000000419; FungiDB:YBR215W; VEuPathDB:YBR215W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA binding activity and nucleosome binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See HPC2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (653356..655317)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Sds24p Neighboring gene Ybp1p Neighboring gene Atg12p

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The histone chaperone gene HPC2 reversed the elevated manganese and phosphate of pho80 mutants by specifically repressing PHO84, encoding a metal-phosphate transporter.
    Title: Phosphate disruption and metal toxicity in Saccharomyces cerevisiae: effects of RAD23 and the histone chaperone HPC2.
  2. the separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes
    Title: Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HIR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Hpc2p
NP_009774.4
  • Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    653356..655317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178563.3 → NP_009774.4  Hpc2p

    See identical proteins and their annotated locations for NP_009774.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBP6, D6VQL1, Q01448
    UniProtKB/TrEMBL
    A6ZLF5
    Conserved Domains (1) summary
    pfam08729
    Location:558 → 601
    HUN; HPC2 and ubinuclein domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01448.2

Gene LinkOut

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