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MET8 bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852514, updated on 29-Jun-2024

Summary

Gene symbol
MET8
Gene description
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
Primary source
FungiDB:YBR213W
Locus tag
YBR213W
See related
SGD:S000000417; AllianceGenome:SGD:S000000417; VEuPathDB:YBR213W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferrochelatase activity and precorrin-2 dehydrogenase activity. Involved in siroheme biosynthetic process and sulfate assimilation. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MET8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (650368..651192)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ame1p Neighboring gene Ngr1p Neighboring gene Sds24p Neighboring gene Hpc2p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables precorrin-2 dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables precorrin-2 dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables precorrin-2 dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables sirohydrochlorin ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in siroheme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in siroheme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfate assimilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
NP_009772.1
  • Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    650368..651192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178561.1NP_009772.1  TPA: bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK9, P15807
    UniProtKB/TrEMBL
    A0A8H4BU61, G2W9L6
    Conserved Domains (1) summary
    COG1648
    Location:2254
    CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]