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MCM7 mini-chromosome maintenance complex protein 7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852501, updated on 9-Sep-2018

Summary

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Gene symbol
MCM7
Gene description
mini-chromosome maintenance complex protein 7
Primary source
SGD:S000000406
Locus tag
YBR202W
Gene type
protein coding
RNA name
mini-chromosome maintenance complex protein 7
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC47

Genomic context

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See MCM7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (625772..628309)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene derlin Neighboring gene hypothetical protein Neighboring gene Cos111p Neighboring gene triacylglycerol lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading. Ticau S, et al. Cell, 2015 Apr 23. PMID 25892223, Free PMC Article
  2. Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Dalton S, et al. Proc Natl Acad Sci U S A, 1995 Mar 28. PMID 7708676, Free PMC Article
  3. Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1. Fitch MJ, et al. J Biol Chem, 2003 Jul 11. PMID 12738768
  4. Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. Schepers A, et al. J Mol Biol, 2001 May 11. PMID 11350163
  5. Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer. Miyazawa-Onami M, et al. EMBO Rep, 2017 Oct. PMID 28818838,

See all (98) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-alpha to Mcm2-7.
    Title: An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7.
  2. The tethering of SCF(Dia2) to the replisome progression complex increases the efficiency of ubiquitylation of the Mcm7 subunit of CMG. Correspondingly, loss of tethering is synthetic lethal in combination with a disassembly-defective allele of CDC48.
    Title: Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.
  3. The data demonstrate that ORC/Cdc6 facilitates directly MCM2-7 dimerization and shows that productive MCM2-7 dimerization is essential for prereplicative complex formation.
    Title: The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.
  4. origin ssDNA may stimulate the formation of the CMG complex by alleviating inhibitory interactions between Sld2 with Mcm2-7.
    Title: Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.
  5. origin single-stranded DNA releases Sld3 from Mcm2-7, allowing GINS to bind Mcm2-7.
    Title: Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex.
  6. The minimal functional unit of Mcm4/6/7 is a hexamer
    Title: The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function.
  7. Analsis of the contribution of two structural motifs, the Walker B box and arginine finger, make to each Mcm2-7 ATPase active site.
    Title: The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.
  8. DNA runs through a central channel in the double hexamer, and, once loaded, Mcm2-7 can slide passively along double-stranded DNA.
    Title: Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
  9. Data indicate that a complex of the GINS and Ctf4 components of the replisome progression complex is crucial to couple MCM2-7 to DNA polymerase alpha.
    Title: A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.
  10. incorporation of Mcm2-7 into the prereplicative complex increased the level and changes the specificity of Dbf4-dependent kinase phosphorylation of this complex
    Title: Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from BioSystems

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  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
    Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell cycle - yeast, organism-specific biosystem (from KEGG)
    Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Cell cycle - yeast, conserved biosystem (from KEGG)
    Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • DNA Replication, organism-specific biosystem (from WikiPathways)
    DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
  • DNA Replication, organism-specific biosystem (from REACTOME)
    DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • DNA replication, organism-specific biosystem (from KEGG)
    DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • DNA replication, conserved biosystem (from KEGG)
    DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • DNA strand elongation, organism-specific biosystem (from REACTOME)
    DNA strand elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MCM complex, organism-specific biosystem (from KEGG)
    MCM complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
  • MCM complex, conserved biosystem (from KEGG)
    MCM complex, conserved biosystemStructural complex; Genetic information processing; Replication system
  • Meiosis - yeast, organism-specific biosystem (from KEGG)
    Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
  • Meiosis - yeast, conserved biosystem (from KEGG)
    Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
  • S Phase, organism-specific biosystem (from REACTOME)
    S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Synthesis of DNA, organism-specific biosystem (from REACTOME)
    Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Unwinding of DNA, organism-specific biosystem (from REACTOME)
    Unwinding of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP-dependent 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP-dependent four-way junction helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
MCM complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
  
hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
single-stranded DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
  
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
DNA replication initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
DNA strand elongation involved in DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
DNA strand elongation involved in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
  
chromatin silencing at silent mating-type cassette IMP
Inferred from Mutant Phenotype
more info
 PubMed 
chromatin silencing at telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
nuclear DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
MCM complex IEA
Inferred from Electronic Annotation
more info
  
MCM core complex IDA
Inferred from Direct Assay
more info
 PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
  
nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
 PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
  
replication fork protection complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mini-chromosome maintenance complex protein 7
NP_009761.4
  • Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    625772..628309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178550.4 → NP_009761.4  TPA: mini-chromosome maintenance complex protein 7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009761.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38132
    Conserved Domains (2) summary
    smart00350
    Location:223 → 724
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:61 → 123
    MCM_N; MCM N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3JA8_7.1
5H7I_7.1
5U8S_7.1
5U8T_7.1
5UDB_7.1
5XF8_7.1
6F0L_7.1
6F0L_F.1
P38132.4

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