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MBA1 Mba1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852483, updated on 7-Jun-2026
Official Symbol
MBA1
Official Full Name
Mba1p
Primary source
SGD:S000000389
Locus tag
YBR185C
See related
AllianceGenome:SGD:S000000389; FungiDB:YBR185C; VEuPathDB:YBR185C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mitochondrial ribosome binding activity. Involved in positive regulation of mitochondrial translation and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (599123..599959, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene phytoceramidase Neighboring gene uncharacterized protein Neighboring gene Pch2p Neighboring gene putative ribosome biosynthesis protein GDT1

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain. Rep M, et al. FEBS Lett, 1996 Jun 17. PMID 8690083
  2. Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. Preuss M, et al. J Cell Biol, 2001 May 28. PMID 11381092, Free PMC Article
  3. Mba1, a membrane-associated ribosome receptor in mitochondria. Ott M, et al. EMBO J, 2006 Apr 19. PMID 16601683, Free PMC Article
  4. Partial suppression of Oxa1 mutants by mitochondria-targeted signal recognition particle provides insights into the evolution of the cotranslational insertion systems. Funes S, et al. FEBS J, 2013 Feb. PMID 23198851
  5. Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery. Sharma N, et al. Biol Chem, 2022 Jul 26. PMID 35100666, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inner mitochondrial membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane from matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
Preferred Names
Mba1p
NP_009744.3
  • Membrane-associated mitoribosome receptor; involved along with Mrx15p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    599123..599959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178533.3 → NP_009744.3  Mba1p

    See identical proteins and their annotated locations for NP_009744.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQI0, P38300
    UniProtKB/TrEMBL
    B3LMX6, B5VED8, C7GQ27, D3UES9, G2W9I7, N1P6X2
    Conserved Domains (1) summary
    pfam07961
    Location:51 → 278
    MBA1; MBA1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38300.1

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