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SMP1 Smp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852480, updated on 8-Sep-2022

Summary

Gene symbol
SMP1
Gene description
Smp1p
Primary source
SGD:S000000386
Locus tag
YBR182C
See related
AllianceGenome:SGD:S000000386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA binding activity, bending and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20 and dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A); MEF2C (myocyte enhancer factor 2C); and MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SMP1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (593506..594864, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Dtr1p Neighboring gene ribosomal 40S subunit protein S6B Neighboring gene uncharacterized protein Neighboring gene phytoceramidase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Smp1p
NP_009741.3
  • MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    593506..594864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178530.3NP_009741.3  TPA: Smp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009741.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQH6, P38128
    UniProtKB/TrEMBL
    A0A8H4BVH8, N1P8L9
    Conserved Domains (2) summary
    COG5068
    Location:130452
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:274
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...