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RPS6B 40S ribosomal protein eS6 RPS6B [ Saccharomyces cerevisiae S288C ]

Gene ID: 852479, updated on 3-Jun-2026
Official Symbol
RPS6B
Official Full Name
40S ribosomal protein eS6 RPS6B
Primary source
SGD:S000000385
Locus tag
YBR181C
See related
AllianceGenome:SGD:S000000385; FungiDB:YBR181C; VEuPathDB:YBR181C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPG18; RPS101; RPS102
Summary
A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm. Part of cytosolic small ribosomal subunit and small-subunit processome. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPS6B in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (591712..592774, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitofusin Neighboring gene Dtr1p Neighboring gene Smp1p Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast contains two functional genes coding for ribosomal protein S10. Leer RJ, et al. Nucleic Acids Res, 1985 Jul 25. PMID 2991849, Free PMC Article
  2. Evolutionary conservation of nuclear and nucleolar targeting sequences in yeast ribosomal protein S6A. Lipsius E, et al. Biochem Biophys Res Commun, 2005 Aug 12. PMID 15979583
  3. Functional interaction in establishment of ribosomal integrity between small subunit protein rpS6 and translational regulator rpL10/Grc5p. Pachler K, et al. FEMS Yeast Res, 2004 Dec. PMID 15556089
  4. The Modular Adaptive Ribosome. Yadav A, et al. PLoS One, 2016. PMID 27812193, Free PMC Article
  5. Saccharomyces cerevisiae nutrient signaling pathways show an unexpected early activation pattern during winemaking. Vallejo B, et al. Microb Cell Fact, 2020 Jun 6. PMID 32505207, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
40S ribosomal protein eS6 RPS6B
NP_009740.3
  • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    591712..592774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178529.3 → NP_009740.3  40S ribosomal protein eS6 RPS6B

    See identical proteins and their annotated locations for NP_009740.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQH5, P02365, P05751, P0CX37, P0CX38, Q02894
    UniProtKB/TrEMBL
    A6ZLC2, C8ZIU0, D3UES5, G2W9I2, G2WP91
    Conserved Domains (1) summary
    cl00931
    Location:1 → 220
    Ribosomal_S6e; Ribosomal protein S6e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX37.1
P0CX38.1

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