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SWD3 Swd3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852472, updated on 15-Jan-2022

Summary

Gene symbol
SWD3
Gene description
Swd3p
Primary source
SGD:S000000379
Locus tag
YBR175W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPS30; SAF35
Summary
Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation; regulation of meiotic DNA double-strand break formation; and telomere organization. Part of Set1C/COMPASS complex. Orthologous to several human genes including WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See SWD3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (582408..583355)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Smy2p Neighboring gene Ump1p Neighboring gene 3-methyl-2-oxobutanoate hydroxymethyltransferase Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone methyltransferase activity (H3-K4 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Swd3p
NP_009734.1
  • Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    582408..583355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178523.1NP_009734.1  TPA: Swd3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009734.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38123
    Conserved Domains (2) summary
    cd00200
    Location:17314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1753
    7WD40; WD40 repeat [structural motif]
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