SWD3 Swd3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SWD3
Official Full Name: Swd3p
Primary source: SGD:S000000379
Locus tag: YBR175W
See related: AllianceGenome:SGD:S000000379; FungiDB:YBR175W; VEuPathDB:YBR175W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CPS30; SAF35
Summary: Contributes to histone H3K4 methyltransferase activity. Involved in regulation of meiotic DNA double-strand break formation; subtelomeric heterochromatin formation; and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human WDR5 (WD repeat domain 5) and WDR5B (WD repeat domain 5B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See SWD3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (582408..583355)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
Title: Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
The affinity of the subunit Spp1 for modified histone H3 substrates is much higher than that of Swd1 and Swd3.
Title: Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to histone H3K4 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H3K4 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of meiotic DNA double-strand break formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	NAS Non-traceable Author Statement more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Swd3p

NP_009734.1

Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

582408..583355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178523.1 → NP_009734.1 Swd3p

See identical proteins and their annotated locations for NP_009734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQH0, P38123

UniProtKB/TrEMBL

A6ZLB7, B3LMY5, B5VEC9, C7GUI9, D3UES0, G2W9H7, N1PAU4

Conserved Domains (2) summary

cd00200
Location:17 → 314

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:17 → 53

7WD40; WD40 repeat [structural motif]