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ARL1 Arf family GTPase ARL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852462, updated on 10-Feb-2026
Official Symbol
ARL1
Official Full Name
Arf family GTPase ARL1
Primary source
SGD:S000000368
Locus tag
YBR164C
See related
AllianceGenome:SGD:S000000368; FungiDB:YBR164C; VEuPathDB:YBR164C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DLP2
Summary
Enables GTPase activity. Involved in several processes, including cellular response to heat; protein localization to phagophore assembly site; and protein transport. Located in cytosol and trans-Golgi network. Is active in phagophore assembly site. Orthologous to human ARL1 (ARF like GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ARL1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (567875..568426, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ysy6p Neighboring gene Exo5p Neighboring gene Ubs1p Neighboring gene prephenate dehydrogenase (NADP(+))

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of an ADP-ribosylation factor-like 1 protein in Saccharomyces cerevisiae. Lee FJ, et al. J Biol Chem, 1997 Dec 5. PMID 9388248
  2. Arf-like GTPases: not so Arf-like after all. Burd CG, et al. Trends Cell Biol, 2004 Dec. PMID 15564045
  3. Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases. Amor JC, et al. J Biol Chem, 2001 Nov 9. PMID 11535602
  4. An ARL1 mutation affected autophagic cell death in yeast, causing a defect in central vacuole formation. Abudugupur A, et al. Cell Death Differ, 2002 Feb. PMID 11840166
  5. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Jochum A, et al. Mol Cell Biol, 2002 Jul. PMID 12052896, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arl3-Arl1 cascade acts on the cytoplasm-to-vacuole targeting pathway via dynamic nucleotide binding
    Title: The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking.
  2. Through this screen, we were able to confirm several membrane traffic and autophagy regulators that have novel relationships with Arl1 and Ypt6 during autophagy
    Title: A High Copy Suppressor Screen for Autophagy Defects in Saccharomyces arl1Δ and ypt6Δ Strains.
  3. Hac1p restored the Golgi localization of Arl1p inIRE1-deleted cells. Ire1p-Hac1p axis regulated Syt1p phosphorylation, which enhances Arl1p activation, recruitment of Imh1p to the Golgi, and Syt1p interaction with Arl1p.
    Title: Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p.
  4. Imh1p and Drs2p modulate the activity of Gcs1p by timing its interaction with Arl1p, hence providing feedback regulation of Arl1p activity.
    Title: Mechanism of action of the flippase Drs2p in modulating GTP hydrolysis of Arl1p.
  5. The authors demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L].
    Title: Mon2 is a negative regulator of the monomeric G protein, Arl1.
  6. results suggest partially overlapping functions of the GTPases in resistance to various stress factors, with Ypt6 being more efficient under physiological conditions and Arl1 more versatile when overexpressed
    Title: Comparison of the influence of small GTPases Arl1 and Ypt6 on yeast cells' tolerance to various stress factors.
  7. gene deletions affecting the Arl1 vesicle-tethering pathways prevent Arl1 activation and membrane localization
    Title: Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast.
  8. The authors conclude that Arl1p, Kha1p and Nhx1p collaborate in survival strategies at nonoptimal pH, temperatures and cation concentrations, but work independent of each other.
    Title: Genetic interactions among the Arl1 GTPase and intracellular Na(+) /H(+) antiporters in pH homeostasis and cation detoxification.
  9. Findings reveal that activation of Arl1p is regulated in part by Syt1p, and imply that Arl1p activation, by using more than one GEF, exerts distinct biological activities at the Golgi compartment.
    Title: Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p.
  10. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
    Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
Submit: New GeneRIF Correction See all GeneRIFs (13)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Arf family GTPase ARL1
NP_009723.3
  • Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    567875..568426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178512.3 → NP_009723.3  Arf family GTPase ARL1

    See identical proteins and their annotated locations for NP_009723.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG0, P38116
    UniProtKB/TrEMBL
    A6ZLA7, B3LMZ4, B5VEC0, C7GUH9, D3UEQ9, G2W9G7, N1P6U6
    Conserved Domains (1) summary
    cd04151
    Location:20 → 177
    Arl1; ADP ribosylation factor 1 (Arf1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38116.4

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