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IFA38 ketoreductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852456, updated on 8-Mar-2025

Summary

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Official Symbol
IFA38
Official Full Name
ketoreductase
Primary source
SGD:S000000363
Locus tag
YBR159W
See related
AllianceGenome:SGD:S000000363; FungiDB:YBR159W; VEuPathDB:YBR159W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ketoreductase activity. Involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum membrane. Used to study cancer; gynecomastia; polycystic kidney disease; and pseudohermaphroditism. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12); HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3); and HSDL1 (hydroxysteroid dehydrogenase like 1). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See IFA38 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (558685..559728)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ics2p Neighboring gene Amn1p Neighboring gene cyclin-dependent serine/threonine-protein kinase CDC28 Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit CSH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of 17beta-hydroxysteroid dehydrogenases in mesophilic and extremophilic yeast. Rizner TL, et al. Steroids, 2001 Jan. PMID 11090658
  2. Rapid functional and evolutionary changes follow gene duplication in yeast. Naseeb S, et al. Proc Biol Sci, 2017 Aug 30. PMID 28835561, Free PMC Article
  3. Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation. Kihara A, et al. J Biol Chem, 2008 Apr 25. PMID 18272525
  4. The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy. Manik MIN, et al. Biochem Biophys Res Commun, 2024 Nov 19. PMID 39232457
  5. Sequence and functional analysis of a 7.2 kb DNA fragment containing four open reading frames located between RPB5 and CDC28 on the right arm of chromosome II. Rose M, et al. Yeast, 1995 Jul. PMID 7483850

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although YBR159W localizes to the endoplasmic reticulum membrane, subcellular fractionation experiments show that a fraction of eIF2B cofractionates with lipid membranes in a YBR159W-independent manner.
    Title: The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ketoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ketoreductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ketoreductase
NP_009717.1
  • Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    558685..559728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178507.1 → NP_009717.1  TPA: ketoreductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009717.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZLA1, B3LN00, D6VQF4, P38286
    UniProtKB/TrEMBL
    B5VEB5, C7GUU5, D3UEQ3, G2W9G1, N1P8A9
    Conserved Domains (1) summary
    cd05356
    Location:62 → 310
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38286.1

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