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ADH5 alcohol dehydrogenase ADH5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852442, updated on 3-Jun-2026
Official Symbol
ADH5
Official Full Name
alcohol dehydrogenase ADH5
Primary source
SGD:S000000349
Locus tag
YBR145W
See related
AllianceGenome:SGD:S000000349; FungiDB:YBR145W; VEuPathDB:YBR145W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable alcohol dehydrogenase (NAD+) activity. Involved in amino acid catabolic process to alcohol via Ehrlich pathway and glycolytic fermentation to ethanol. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ADH5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (533762..534817)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation termination factor eRF1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein uS9m MRPS9 Neighboring gene cationic amino acid transporter

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. NADP-dependent alcohol dehydrogenases in bacteria and yeast: purification and partial characterization of the enzymes from Acinetobacter calcoaceticus and Saccharomyces cerevisiae. Wales MR, et al. Microbiology (Reading), 1994 Jan. PMID 8162187
  2. Kluyveromyces marxianus exhibits an ancestral Saccharomyces cerevisiae genome organization downstream of ADH2. Ladrière JM, et al. Gene, 2000 Sep 5. PMID 10974568
  3. Microbial synergy via an ethanol-triggered pathway. Smith MG, et al. Mol Cell Biol, 2004 May. PMID 15082781, Free PMC Article
  4. Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol. Plapp BV, et al. Arch Biochem Biophys, 2016 Feb 1. PMID 26743849
  5. Yeast alcohol dehydrogenase: molecular weight, coenzyme binding, and reaction equilibria. HAYES JE Jr, et al. J Biol Chem, 1954 Mar. PMID 13152098

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables alcohol dehydrogenase (NAD+) activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables indole-3-acetaldehyde reductase (NADH) activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-isoleucine catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in L-leucine catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-leucine catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in L-phenylalanine catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in L-tryptophan catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in L-tyrosine catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in L-valine catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in ethanol catabolic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in pyruvate fermentation to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
located_in nucleus HDA PubMed 
Preferred Names
alcohol dehydrogenase ADH5
NP_009703.3
  • Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    533762..534817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178493.3 → NP_009703.3  alcohol dehydrogenase ADH5

    See identical proteins and their annotated locations for NP_009703.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQE0, P38113
    UniProtKB/TrEMBL
    A6ZL87, B3LN13, B5VEA1, C7GY26, D3UEP0, G2W9E7, N1PAT7
    Conserved Domains (1) summary
    cd08297
    Location:10 → 347
    CAD3; Cinnamyl alcohol dehydrogenases (CAD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38113.1

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