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MEC1 protein kinase MEC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852433, updated on 12-Aug-2018

Summary

Gene symbol
MEC1
Gene description
protein kinase MEC1
Primary source
SGD:S000000340
Locus tag
YBR136W
Gene type
protein coding
RNA name
protein kinase MEC1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ESR1; RAD31; SAD3

Genomic context

See MEC1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (505668..512774)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene protein arginine N-methyltransferase Neighboring gene cyclin-dependent protein kinase regulatory subunit CKS1 Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage induced protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
histone phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-dependent DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein kinase MEC1
NP_009694.3
  • Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    505668..512774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178484.3NP_009694.3  TPA: protein kinase MEC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009694.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38111
    Conserved Domains (1) summary
    COG5032
    Location:1942368
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
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