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AGP2 Agp2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852429, updated on 24-Jan-2026
Official Symbol
AGP2
Official Full Name
Agp2p
Primary source
SGD:S000000336
Locus tag
YBR132C
See related
AllianceGenome:SGD:S000000336; FungiDB:YBR132C; VEuPathDB:YBR132C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable amino acid transmembrane transporter activity. Involved in positive regulation of (R)-carnitine transmembrane transport and positive regulation of polyamine transmembrane transport. Located in endoplasmic reticulum membrane; fungal-type vacuole membrane; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to human SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (499652..501442, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene She3p Neighboring gene Ccz1p Neighboring gene protein arginine N-methyltransferase Neighboring gene cyclin-dependent protein kinase regulatory subunit CKS1

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional analysis of OsPUT1, a rice polyamine uptake transporter. Mulangi V, et al. Planta, 2012 Jan. PMID 21796369
  2. Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway. Lee J, et al. Mol Cells, 2002 Jun 30. PMID 12132580
  3. A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin. Aouida M, et al. Cancer Res, 2004 Feb 1. PMID 14871844
  4. Putative ancient microorganisms from amber nuggets. Veiga-Crespo P, et al. Int Microbiol, 2007 Jun. PMID 17661290
  5. Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions. Schreve JL, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697254

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Agp2 might respond to environmental cues and thus regulate the expression of several genes including those involved in polyamine transport.
    Title: Agp2, a member of the yeast amino acid permease family, positively regulates polyamine transport at the transcriptional level.
  2. AGP2 encodes the first eukaryotic permease that preferentially uses spermidine over putrescine as a high affinity substrate and plays a central role in the uptake of polyamines in yeast
    Title: AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of (R)-carnitine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of polyamine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Agp2p
NP_009690.1
  • Plasma membrane regulator of high affinity polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; null mutant is cycloheximide (CHX) resistant; ubiquitinated Agp2p is rapidly degraded in a Brp1p-dependent manner in the presence of CHX; localizes to the plasma membrane, the vacuolar membrane and the ER membrane

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    499652..501442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178480.1 → NP_009690.1  Agp2p

    See identical proteins and their annotated locations for NP_009690.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC9, P38090
    UniProtKB/TrEMBL
    B5VE93, G2W9D6
    Conserved Domains (1) summary
    COG0833
    Location:41 → 596
    LysP; Amino acid permease [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38090.1

Gene LinkOut

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