U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TEF2 translation elongation factor EF-1 alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 852415, updated on 6-Jul-2026
Official Symbol
TEF2
Official Full Name
translation elongation factor EF-1 alpha
Primary source
SGD:S000000322
Locus tag
YBR118W
See related
AllianceGenome:SGD:S000000322; FungiDB:YBR118W; VEuPathDB:YBR118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables translation elongation factor activity. Involved in translational elongation. Is active in cytosol. Used to study developmental and epileptic encephalopathy 33; dilated cardiomyopathy; and epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; epilepsy; and ovarian cancer. Orthologous to several human genes including EEF1A1 (eukaryotic translation elongation factor 1 alpha 1) and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TEF2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (477671..479047)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene transketolase TKL2 Neighboring gene Mud1p Neighboring gene Cbp6p

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Optimized purification workflow for advanced eEF1A studies: Impact of His-tagging on stability, functionality, and yield. Madsen PN, et al. Anal Biochem, 2026 Mar. PMID 41344549
  2. Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation. Eltschinger S, et al. PLoS One, 2012. PMID 22860115, Free PMC Article
  3. A novel post-translational modification of yeast elongation factor 1A. Methylesterification at the C terminus. Zobel-Thropp P, et al. J Biol Chem, 2000 Nov 24. PMID 10973948
  4. Site-directed mutagenesis of yeast eEF1A. Viable mutants with altered nucleotide specificity. Cavallius J, et al. J Biol Chem, 1998 Oct 30. PMID 9786872
  5. Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. Jank T, et al. J Biol Chem, 2017 Sep 29. PMID 28801462, Free PMC Article

See all (196) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutational analysis reveals potential phosphorylation sites in eukaryotic elongation factor 1A that are important for its activity.
    Title: Mutational analysis reveals potential phosphorylation sites in eukaryotic elongation factor 1A that are important for its activity.
  2. the Rho1p-eEF1A complex acts to spatially localize a pool of eEF1A to vacuoles where it can readily organize F-actin.
    Title: Yeast translation elongation factor-1A binds vacuole-localized Rho1p to facilitate membrane integrity through F-actin remodeling.
  3. Elongation factor 1A (EF-1A) competes with the RTD pathway for substrate tRNAs, since its overexpression suppresses the tRNA degradation and the growth defect of strains subject to RTD, whereas reduced levels of EF-1A have the opposite effect.
    Title: The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications.
  4. The actin bundling activity of eukaryotic translation elongation factor 1A is not required for protein synthesis functions but is essential for cytoskeletal integrity. [eEF1A]
    Title: Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-aminoacyl-tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables melatonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol HDA PubMed 
located_in cytosol HDA PubMed 
part_of eukaryotic translation elongation factor 1 complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
translation elongation factor EF-1 alpha
NP_009676.1
  • Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus; Tef2p-RFP levels increase during replicative aging

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    477671..479047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178466.1 → NP_009676.1  translation elongation factor EF-1 alpha

    See identical proteins and their annotated locations for NP_009676.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQB6, P02994, Q7Z7U8, Q7Z8Q8, Q7Z8Q9
    UniProtKB/TrEMBL
    B3LK50
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 443
    PTZ00141; elongation factor 1- alpha; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02994.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.