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TKL2 transketolase TKL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852414, updated on 9-Jul-2017
Gene symbol
TKL2
Gene description
transketolase TKL2
Primary source
SGD:S000000321
Locus tag
YBR117C
Gene type
protein coding
RNA name
transketolase TKL2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See TKL2 in Map Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (474392..476437, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD16 Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Mud1p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
metabolic process IEA
Inferred from Electronic Annotation
more info
 
pentose-phosphate shunt IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
transketolase TKL2
NP_009675.3
  • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    474392..476437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178465.3NP_009675.3  TPA: transketolase TKL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009675.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P33315
    Conserved Domains (4) summary
    TIGR00232
    Location:9665
    tktlase_bact; transketolase, bacterial and yeast
    pfam00456
    Location:7339
    Transketolase_N; Transketolase, thiamine diphosphate binding domain
    pfam02779
    Location:354533
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam02780
    Location:546657
    Transketolase_C; Transketolase, C-terminal domain
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