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TKL2 transketolase TKL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852414, updated on 27-Jan-2024

Summary

Gene symbol
TKL2
Gene description
transketolase TKL2
Primary source
SGD:S000000321
Locus tag
YBR117C
See related
AllianceGenome:SGD:S000000321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transketolase activity. Involved in pentose-phosphate shunt. Located in cytoplasm and nucleus. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See TKL2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (474392..476437, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD16 Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Mud1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
 
enables transketolase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
transketolase TKL2
NP_009675.3
  • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    474392..476437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178465.3NP_009675.3  TPA: transketolase TKL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009675.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQB5, P33315
    UniProtKB/TrEMBL
    A0A6A5Q1W7, A6ZL62, B3LN38, B5VE78, C7GUL3, D3UEK9, G2W9C2, N1PAT1
    Conserved Domains (1) summary
    TIGR00232
    Location:9665
    tktlase_bact; transketolase, bacterial and yeast