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RXT2 Rxt2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852392, updated on 16-Mar-2025

Summary

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Official Symbol
RXT2
Official Full Name
Rxt2p
Primary source
SGD:S000000299
Locus tag
YBR095C
See related
AllianceGenome:SGD:S000000299; FungiDB:YBR095C; VEuPathDB:YBR095C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RAF60
Summary
Contributes to histone deacetylase activity. Involved in several processes, including invasive growth in response to glucose limitation; negative regulation of heterochromatin formation; and positive regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See RXT2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (434406..435698, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene acid phosphatase PHO5 Neighboring gene putative tubulin tyrosine ligase Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding serine/threonine protein kinase VPS15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum. Mogg C, et al. mBio, 2019 Jun 11. PMID 31186319, Free PMC Article
  2. Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. Colina AR, et al. J Biol Chem, 2005 Dec 30. PMID 16275642
  3. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article
  4. Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast. Bumgarner SL, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19805129, Free PMC Article
  5. Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. Sardiu ME, et al. PLoS One, 2009 Oct 6. PMID 19806189, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L complex HDA PubMed 
part_of Rpd3L complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rxt2p
NP_009653.2
  • Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    434406..435698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178443.1 → NP_009653.2  TPA: Rxt2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009653.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ96, P38255
    UniProtKB/TrEMBL
    D3UEJ0, G2W9A2, N1P848
    Conserved Domains (1) summary
    pfam08595
    Location:62 → 221
    RXT2_N; RXT2-like, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38255.2

Gene LinkOut

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