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H2AC12 H2A clustered histone 12 [ Homo sapiens (human) ]

Gene ID: 85235, updated on 25-Nov-2021

Summary

Official Symbol
H2AC12provided by HGNC
Official Full Name
H2A clustered histone 12provided by HGNC
Primary source
HGNC:HGNC:13671
See related
Ensembl:ENSG00000274997 MIM:615013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2AH; H2A/S; H2AFALii; HIST1H2AH; dJ86C11.1
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC12 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27147106..27147562)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27114885..27115341)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 11 Neighboring gene H2B clustered histone 12 Neighboring gene H4 clustered histone 9 Neighboring gene microRNA 3143 Neighboring gene tRNA-Val (anticodon CAC) 9-1

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC171151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H2A type 1-H
Names
H2A histone family member
histone H2A/s
histone cluster 1 H2A family member h
histone cluster 1, H2ah

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080596.3NP_542163.1  histone H2A type 1-H

    See identical proteins and their annotated locations for NP_542163.1

    Status: REVIEWED

    Source sequence(s)
    AL021807
    Consensus CDS
    CCDS4622.1
    UniProtKB/Swiss-Prot
    Q96KK5
    UniProtKB/TrEMBL
    A3KPC7
    Related
    ENSP00000366679.2, ENST00000377459.3
    Conserved Domains (1) summary
    PTZ00017
    Location:1123
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27147106..27147562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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