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CSG2 mannosylinositol phosphorylceramide synthase regulatory subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 852324, updated on 14-Sep-2025
Official Symbol
CSG2
Official Full Name
mannosylinositol phosphorylceramide synthase regulatory subunit
Primary source
SGD:S000000240
Locus tag
YBR036C
See related
AllianceGenome:SGD:S000000240; FungiDB:YBR036C; VEuPathDB:YBR036C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS2
Summary
Enables enzyme regulator activity and intracellularly gated calcium channel activity. Involved in endoplasmic reticulum calcium ion homeostasis; glycosphingolipid biosynthetic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in endoplasmic reticulum and fungal-type vacuole. Is active in endoplasmic reticulum membrane. Used to study Charcot-Marie-Tooth disease. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CSG2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (309081..310313, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cu-binding protein SCO1 Neighboring gene chitin synthase CHS2

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae. Beeler T, et al. J Biol Chem, 1994 Mar 11. PMID 8125941
  2. Mutations in GDAP1 Influence Structure and Function of the Trans-Golgi Network. Binięda K, et al. Int J Mol Sci, 2021 Jan 18. PMID 33477664, Free PMC Article
  3. The CLS2 gene encodes a protein with multiple membrane-spanning domains that is important Ca2+ tolerance in yeast. Takita Y, et al. Mol Gen Genet, 1995 Feb 6. PMID 7854312
  4. Pathogenic Effect of GDAP1 Gene Mutations in a Yeast Model. Rzepnikowska W, et al. Genes (Basel), 2020 Mar 14. PMID 32183277, Free PMC Article
  5. Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. Gable K, et al. J Biol Chem, 2002 Mar 22. PMID 11781309

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
    Title: The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
  2. Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
    Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables intracellularly gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannosyl diphosphorylinositol ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
part_of mannosyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mannosyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mannosylinositol phosphorylceramide synthase regulatory subunit
NP_009592.1
  • Calcium release channel involved in ER calcium homeostasis; integrates ER calcium release with the regulation of sphingolipid metabolism and autophagy; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; endoplasmic reticulum membrane protein; contains 10 transmembrane domains and a potential Ca2+ EF-hand motif; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    309081..310313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178384.1 → NP_009592.1  TPA: mannosylinositol phosphorylceramide synthase regulatory subunit

    See identical proteins and their annotated locations for NP_009592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ36, P35206
    UniProtKB/TrEMBL
    A6ZKY0, B3LNA9, B5VE02, C7GXX6, D3UED2, N1P9C8
    Conserved Domains (1) summary
    pfam16965
    Location:1 → 403
    CSG2; Ceramide synthase regulator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35206.2

Gene LinkOut

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