CDS1 phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CDS1
Official Full Name: phosphatidate cytidylyltransferase
Primary source: SGD:S000000233
Locus tag: YBR029C
See related: AllianceGenome:SGD:S000000233; FungiDB:YBR029C; VEuPathDB:YBR029C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDG1
Summary: Enables phosphatidate cytidylyltransferase activity. Involved in CDP-diacylglycerol biosynthetic process; phosphatidylinositol metabolic process; and phosphatidylserine metabolic process. Located in Golgi to plasma membrane transport vesicle and endoplasmic reticulum. Used to study cancer. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	RCA inferred from Reviewed Computational Analysis more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CDP-diacylglycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CDP-diacylglycerol biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in lipid droplet formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
located_in Golgi to plasma membrane transport vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

NP_009585.1

Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant