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POA1 ADP-ribose 1''-phosphate phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852310, updated on 12-Aug-2025
Official Symbol
POA1
Official Full Name
ADP-ribose 1''-phosphate phosphatase
Primary source
SGD:S000000226
Locus tag
YBR022W
See related
AllianceGenome:SGD:S000000226; FungiDB:YBR022W; VEuPathDB:YBR022W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity and phosphatase activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See POA1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (283738..284271)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene galactokinase Neighboring gene uracil permease Neighboring gene chitin synthase CHS3 Neighboring gene putative thioredoxin peroxidase SCO2

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A biochemical genomics approach for identifying genes by the activity of their products. Martzen MR, et al. Science, 1999 Nov 5. PMID 10550052
  2. A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Shull NP, et al. Nucleic Acids Res, 2005. PMID 15684411, Free PMC Article
  3. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474712, Free PMC Article
  4. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article
  5. The macro domain is an ADP-ribose binding module. Karras GI, et al. EMBO J, 2005 Jun 1. PMID 15902274, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of POA1 as a phosphatase with activity on ADP-ribose 1''-phosphate.
    Title: A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
ADP-ribose 1''-phosphate phosphatase
NP_009578.1
  • Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    283738..284271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178370.1 → NP_009578.1  TPA: ADP-ribose 1''-phosphate phosphatase

    See identical proteins and their annotated locations for NP_009578.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZKW8, D6VQ24, P38218
    UniProtKB/TrEMBL
    A0A0L8VVC2, B3LNB9, B5VDZ1, C7GM30, C8Z416, N1P6E4
    Conserved Domains (1) summary
    COG2110
    Location:1 → 174
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38218.1

Gene LinkOut

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