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MNN2 alpha-1,2-mannosyltransferase MNN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852303, updated on 14-Nov-2024

Summary

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Official Symbol
MNN2
Official Full Name
alpha-1,2-mannosyltransferase MNN2
Primary source
SGD:S000000219
Locus tag
YBR015C
See related
AllianceGenome:SGD:S000000219; FungiDB:YBR015C; VEuPathDB:YBR015C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRV4; LDB8; TTP1
Summary
Enables alpha-1,2-mannosyltransferase activity. Involved in protein glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MNN2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (267710..269503, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene glutathione-disulfide reductase GRX7 Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1 Neighboring gene Kap104p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a gene and protein required for glycosylation in the yeast Golgi. Devlin C, et al. Mol Microbiol, 1990 Nov. PMID 2082155
  2. Localization of alpha 1----3-linked mannoses in the N-linked oligosaccharides of Saccharomyces cerevisiae mnn mutants. Alvarado E, et al. Biochemistry, 1990 Mar 13. PMID 2185827
  3. Regulation of the protein glycosylation pathway in yeast: structural control of N-linked oligosaccharide elongation. Gopal PK, et al. Proc Natl Acad Sci U S A, 1987 Dec. PMID 3321055, Free PMC Article
  4. Carbohydrate structure of Saccharomyces cerevisiae mnn9 mannoprotein. Tsai PK, et al. J Biol Chem, 1984 Mar 25. PMID 6368551
  5. The nucleotide sequence of TTP1, a gene encoding a predicted type II membrane protein. Romero PA, et al. Yeast, 1994 Aug. PMID 7992511

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mannan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-mannosyltransferase MNN2
NP_009571.1
  • Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    267710..269503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178363.1 → NP_009571.1  TPA: alpha-1,2-mannosyltransferase MNN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009571.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ17, P38069
    UniProtKB/TrEMBL
    A6ZKW1, B3LNC6, C7GM37, C8Z409
    Conserved Domains (1) summary
    pfam11051
    Location:170 → 440
    Mannosyl_trans3; Mannosyltransferase putative
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38069.1

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