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HHT1 histone H3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852295, updated on 6-Jul-2026
Official Symbol
HHT1
Official Full Name
histone H3
Primary source
SGD:S000000214
Locus tag
YBR010W
See related
AllianceGenome:SGD:S000000214; FungiDB:YBR010W; VEuPathDB:YBR010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BUR5; SIN2
Summary
Enables cupric reductase (NADH) activity. Involved in several processes, including global genome nucleotide-excision repair; intracellular copper ion homeostasis; and rRNA transcription. Located in nucleus. Part of CENP-A containing nucleosome. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Orthologous to several human genes including H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See HHT1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (256331..256741)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Flr1p Neighboring gene histone H4 Neighboring gene inorganic diphosphatase IPP1 Neighboring gene gag protein Neighboring gene gag-pol fusion protein

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of lysine 56 of histone H3 as an acetylation site in Saccharomyces cerevisiae. Ozdemir A, et al. J Biol Chem, 2005 Jul 15. PMID 15888442
  2. Divergence and selectivity of expression-coupled histone modifications in budding yeasts. Mosesson Y, et al. PLoS One, 2014. PMID 25007273, Free PMC Article
  3. Synthesis of yeast histone 3 in an Escherichia coli cell-free system. Mellado RP, et al. J Mol Biol, 1983 Aug 15. PMID 6350605
  4. Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae. McBurney KL, et al. Genetics, 2016 Jan. PMID 26534951, Free PMC Article
  5. The primary structure of yeast histone H3. Brandt WF, et al. Eur J Biochem, 1982 Jan. PMID 7035169

See all (699) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
    Title: The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
  2. Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
    Title: Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
  3. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
    Title: A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
  4. Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
    Title: Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
  5. A model has been proposed wherein combined actions of Set1 and Jhd2 via modulating H3K4 methylation-demethylation together control chromatin dynamics during various facets of transcriptional regulation.
    Title: Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription.
  6. Data indicate histone post-translational modifications (PTMs) enriched at a DNA double-strand break (DSB) site.
    Title: Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
  7. Sas3 and Ada2-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene.
    Title: Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene.
  8. The mutant ion at Histone H3 doesn't affect the recruitment of Pol II repressor RENT (regulator of nucleolar silencing and telophase exit) complex at the Ribosomal DNA region.
    Title: Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging.
  9. Pkc1 also enhances H3T45 phosphorylation and this modification is required for H3K56 acetylation.
    Title: Protein kinase C coordinates histone H3 phosphorylation and acetylation.
  10. results suggest that divergent amino acids within the histone H3 alpha3 helix play organismal roles in defining chromatin structure
    Title: Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction See all GeneRIFs (21)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables cupric reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cupric reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chromatin organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in global genome nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sexual sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CENP-A containing nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I upstream activating factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleosome TAS
Traceable Author Statement
more info
 PubMed 
part_of nucleosome TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
histone H3
NP_009564.1
  • Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    256331..256741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178358.1 → NP_009564.1  histone H3

    See identical proteins and their annotated locations for NP_009564.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ11, E9PAG1, P02303, P13996, P61830, Q6B1U3, Q6Q7G9
    UniProtKB/TrEMBL
    B3LND0
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61830.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials